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KMID : 0387420090200030035
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Korean Society of Oriental Neuropsychiatry
2009 Volume.20 No. 3 p.35 ~ p.48
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Effects of Pinelliae Rhizoma Extract on Sociopsychological Stress
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Kim Su-Youn
Kim Kyeong-Ok
Choi Chang-Won
Cho Su-In
Lim Se-Hyun
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Abstract
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Objectives: The effects of Pinelliae Rhizoma extract(PRe) were tested for the anti-stress action.
Methods: PRe was fed to ICR male mice(20±2g) orally with the dose of 100 mg/kg/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days.
Results: PRe administration had the effect of decreasing serum level of lipid peroxidation. The elevated plus-maze test is designed to detect the effect of anxiolytic drugs,and PRe administration group showed a significant increase of latency time. From Microarray, common features between mind-stimulus related genes and body-stimulus related genes were not so abundant When PRe was administered, there were some changes in distributions of mind-stimulus related genes but the distributions were not recovered to normal status.
Conclusions: These results suggest that PRe can effectively rid the sociopsychological stress and stress concrened diseases.
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KEYWORD
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Pinelliae Rhizoma Extract(PRe), Stress, Corticosterone, Noradrenaline, Anti-anxiety Agents, Microarray Analysis
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